ORBITA CTO: The Sham-Controlled Trial That Shook CTO-PCI

In this episode host Ashish Pershad reviews the ORBITA CTO randomized, double-blind, sham-controlled trial that compared CTO-PCI to a placebo procedure, explaining the rigorous design, patient selection, masking methods, and statistical approach.

Pershad summarizes the results showing significant symptom improvement with CTO-PCI, discusses clinical implications—blinding, careful case selection, and specialist referral—and outlines how this trial advances evidence for procedural interventions for patients with stable angina.